
Lion's mane ( Hericium erinaceus ) is attracting growing interest due to its promising properties for brain and nerve health. Given its popularity, it is vital to thoroughly understand not only its benefits, but also its contraindications and potential adverse effects for responsible and informed consumption.
This mushroom, traditionally used in Asia, is generally considered safe , but like any active substance, it interacts with our bodies in complex ways.
Understanding who should exercise caution or avoid its use is critical to reaping its benefits without taking unnecessary risks. This article delves into the safety of Hericium erinaceus .

What adverse reactions can lion's mane have?
Although tolerance is generally excellent, some people may experience reactions when taking lion's mane. It's important to distinguish between mild side effects and more serious allergic reactions, although both are rare.
- Digestive discomfort: Symptoms such as bloating, gas, or mild diarrhea may occur. This may be due to the fiber content of the mushroom or an individual intestinal sensitivity. They are usually temporary and can be alleviated by starting with low doses.
- Skin reactions: The appearance of itching (pruritus) or a rash is uncommon, but it may indicate a hypersensitivity or allergic reaction. The immune system mistakenly identifies components of the fungus as a threat.
- Respiratory symptoms: In very rare cases, it may trigger respiratory distress or worsen asthma in susceptible individuals. This is also linked to allergic mechanisms and requires immediate medical attention if it occurs.
Most of these effects are anecdotal or reported in limited studies . However, being aware of them helps identify any signs of personal intolerance. The lack of standardization in some products could also influence the variability of observed reactions.
Who is this mushroom not recommended for?
Here we detail the situations where lion's mane contraindications are most relevant . Caution is key if you identify with any of these profiles.
- Allergy to fungi: This is the clearest contraindication. If you have a diagnosed allergy to other fungi, there is a significant risk of cross-reaction with Hericium erinaceus . Allergy symptoms can range from mild (hives, itching) to severe (anaphylaxis). When in doubt, avoidance is the rule. For more general information on food allergies, you can consult sources such as the Spanish Society of Allergology and Clinical Immunology (SEAIC) or AEPNAA .
- Coagulation disorders and surgery: Preliminary research, particularly in vitro , suggests that lion's mane may inhibit platelet aggregation, i.e., have a mild "anticoagulant" effect. Although clinical evidence in humans is limited and inconclusive, caution is warranted.
People with hemophilia or other bleeding disorders should consult their hematologist. Those taking anticoagulant drugs (warfarin, acenocoumarol - Sintrom®) or new oral anticoagulants (rivaroxaban, apixaban, etc.), as well as antiplatelet agents (aspirin, clopidogrel), should be especially cautious. The combination could theoretically increase the risk of bleeding.
It is recommended to discontinue lion's mane consumption at least two weeks before elective surgery to minimize any intraoperative or postoperative bleeding risk.
- Pregnancy and breastfeeding: There are no adequate and well-controlled studies on the use of lion's mane during pregnancy or breastfeeding. Due to this lack of data on safety for mother and baby, the precautionary principle applies: its use is not recommended during these stages.
- Asthma and severe allergies: Individuals with severe bronchial asthma or a history of multiple allergies (atopic) may have a greater overall reactivity. Although this is not an absolute contraindication, they should begin consumption with extreme caution and under supervision if they decide to do so, given the allergenic potential (albeit low) of any mushroom.
- Diabetes Treatment: There is evidence to suggest that Hericium erinaceus may help regulate blood glucose levels, possibly by improving insulin sensitivity or inhibiting certain digestive enzymes. While this may be beneficial, it poses a risk of hypoglycemia (low blood sugar) if combined with insulin or oral antidiabetic medications (metformin, sulfonylureas, etc.) without adjustment.
It's essential not to self-adjust your medication . Always consult your doctor or endocrinologist before adding lion's mane to your regimen if you have diabetes. You may need to monitor your glucose more frequently at first. - Autoimmune diseases and immunosuppressive treatments: Lion's mane may modulate immune response. If you suffer from an autoimmune disease (such as rheumatoid arthritis, lupus, or multiple sclerosis) or are undergoing immunosuppressive treatment (after a transplant, for example), the mushroom's effect could, theoretically, interfere with your immune response. Consult your specialist, as the evidence is still limited and the effects are complex.

Are side effects common with Lion's Mane?
Lion's mane side effects are very rare . Its long history of use in traditional Asian medicine, combined with modern studies, supports a favorable safety profile for the general population. The key is often the dosage and quality of the product.
Compared to many other supplements or medications, the risks associated with Hericium erinaceus are low. Most mild adverse reactions can be managed by discontinuing use or adjusting the dosage. Learn about the recommended dosage and how to take lion's mane for optimal use.
What to do if you experience adverse reactions
If you suspect that Lion's Mane is causing you any side effects:
- Stop taking: Immediately stop taking the supplement.
- Observe the symptoms: Write down what you feel, when it started and its intensity.
- Consult a professional: Contact your doctor or pharmacist, especially if symptoms are bothersome, persistent, or worrying (such as difficulty breathing or a severe allergic reaction). Do not hesitate to seek urgent medical attention if necessary.
The importance of supplement quality
Not all lion's mane supplements are created equal, as we made clear in our post on the best lion's mane brands . The concentration of active ingredients, the presence of fillers, contaminants (heavy metals, pesticides), or hidden allergens can vary greatly.
Choosing a high-quality product, preferably with third-party testing certifying its purity and potency, is crucial for safety and effectiveness. Consider doing your research on how to choose a good option, and don't just look at the price of lion's mane .
In short, this medicinal mushroom is fascinating, with considerable therapeutic potential and a good overall safety profile. However, ignoring the contraindications of lion's mane would be unwise, as with any other supplement.
Disclaimer: This article is for informational purposes only and does not replace professional medical advice. Always consult your doctor before starting any new supplement.